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Frequent attack in the path c:\windows\System32 -reg

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I need a solution

  we have SEPM  & 100 clients attached to it with SEP 12.1 2015 2015 running..But recently I am observing lot of attacks in the above path.Though Virus is detected and deleted by Auto protect scan then & there,it is repeated often.Windows Updates has been done on all the clients.The virus in Quarentine will it affect the system?I have attached the Risk Log for kind info.These attacks are normal or any action has to be done ?.Please guide.


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