Advise needed on PGP mail settings

Please could somebody advise the best practise configuration for the following:

Running PGP 3.2.1 MP5 with managed PGP Desktop

Mail policy should be controlled by the PGP server. The enviroment is as follows:

client ==> Exchange ==> PGP Universal server ==> Fortimail ==> Internet

I have created a unified mail proxy to handle mail both ways. An auto matic mail route was created for the domain pointing to the exchange server

There is 1 managed domain which equals the mails addresses e.g. client.emaildomain and 1 mail route as mentioned above. Do I need this route or must I create a wildcard route?

Do I need to include a local windows domain example client.local as a manged domain?.

is there anything else I need to do?